First Breakout with supplements?! [evening primrose oil] [flax oil]

Can someone just starting one or more of the following supplements experience a first breakthrough?

Chromium 400mg
Saw Palmetto 320mg
Biotin 500mg
Vitex 400mg
Barleans Primrose Oil Flax Oil
Alpha lipoic Acid
Evening 500mg

Has someone got a first separation of one of these?

How long after first taking the supplement (s) for the first break-out (if it is to begin) to actually present on the skin itself?

For someone not to use or think of using these supplements, what other supplements, people have initial breakouts?

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